Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects
نویسندگان
چکیده
منابع مشابه
Levosimendan, a new inotropic and vasodilator agent.
Several clinical studies suggest substantial limitations of currently available positive inotropic substances, including beta1-adrenoceptor agonists and phosphodiesterase III inhibitors in the short- and long-term treatment of heart failure. The reasons for these detrimental effects are related to the mechanism of action of these drugs, including increases in intracellular Ca2+ with subsequent ...
متن کاملPharmacology of positive inotropic phosphodiesterase III inhibitors.
Cardiac phosphodiesterase III (PDE) inhibitors derived from pyridinone, imidazolone, pyridazinone and related structures form a new class of positive inotropic vasodilator agents (e.g. milrinone) that are beneficial in the treatment of acute and chronic heart failure. These agents inhibit the intracellular hydrolysis of cyclic AMP, thereby promoting cyclic AMP-catalysed phosphorylation of sarco...
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During reperfusion, cardiodepressive factors are released from isolated rat hearts after ischemia. The present study analyzes the mechanisms by which these substances mediate their cardiodepressive effect. After 10 min of global stop-flow ischemia, rat hearts were reperfused and coronary effluent was collected over a period of 30 s. We tested the effect of this postischemic effluent on systolic...
متن کاملInotropic and cardioprotective effects of Daucus carota Linn. on isoproterenol-induced myocardial infarction
Daucus carota Linn. (Family: Umbeliferae) is an annual or biennial herb, whose roots are eaten raw and also cooked in many parts of the world. It is cultivated extensively through out the world including India. The root of the plant is used as a diuretic and inotropic (Chaterjee and Prakesh, 1995). The volatile oil from the seeds are reported to possess analgesic and anti-inflammatory activity ...
متن کاملLevosimendan: beyond its simple inotropic effect in heart failure.
Classic inotropic agents provide short-term haemodynamic improvement in patients with heart failure, but their use has been associated with poor prognosis. A new category of inotropic agents, the Ca(2+) sensitizers, may provide an alternative longer lasting solution. Levosimendan is a relatively new Ca(2+) sensitizer which offers haemodynamic and symptomatic improvement by combining a positive ...
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ژورنال
عنوان ژورنال: Journal of Clinical Pharmacy and Therapeutics
سال: 2013
ISSN: 0269-4727
DOI: 10.1111/jcpt.12067